Zero-point energy (ZPE) is the difference between the lowest possible energy that a quantum mechanical system may have, and the classical minimum energy of the system. Unlike in classical mechanics, quantum systems constantly fluctuate in their lowest energy state due to the Heisenberg uncertainty principle.
As well as atoms and molecules, the empty space of the vacuum has these properties. According to quantum field theory, the universe can be thought of not as isolated particles but continuous fluctuating fields: matter fields, whose quanta are fermions (i.e. leptons and quarks), and force fields, whose quanta are bosons (e.g. photons and gluons). All these fields have zero-point energy.
These fluctuating zero-point fields lead to a kind of reintroduction of an aether in physics, since some systems can detect the existence of this energy. However this aether cannot be thought of as a physical medium if it is to be Lorentz invariant such that there is no contradiction with Einstein's theory of special relativity.

Liquid helium retains kinetic energy and does not freeze regardless of temperature due to zero-point energy. When cooled below its Lambda point, it exhibits properties of superfluidity.
Physics currently lacks a full theoretical model for understanding zero-point energy; in particular the discrepancy between theorized and observed vacuum energy is a source of major contention. Physicists Richard Feynman and John Wheeler calculated the zero-point radiation of the vacuum to be an order of magnitude greater than nuclear energy, with a single light bulb containing enough energy to boil all the world's oceans.
Yet according to Einstein's theory of general relativity any such energy would gravitate and the experimental evidence from both the expansion of the universe, dark energy and the Casimir effect show any such energy to be exceptionally weak. A popular proposal that attempts to address this issue is to say that the fermion field has a negative zero-point energy while the boson field has positive zero-point energy and thus these energies somehow cancel each other out.
This idea would be true if supersymmetry were an exact symmetry of nature. However, the LHC at CERN has so far found no evidence to support supersymmetry. Moreover, it is known that if supersymmetry is valid at all, it is at most a broken symmetry, only true at very high energies, and no one has been able to show a theory where zero-point cancellations occur in the low energy universe we observe today.
This discrepancy is known as the cosmological constant problem and it is one of the greatest unsolved mysteries in physics. Many physicists believe that "the vacuum holds the key to a full understanding of nature".

In 2014 NASA's
Eagleworks Laboratories announced that they had successfully validated the use of a
Quantum Vacuum Plasma Thruster which makes use of the
Casimir effect for propulsion. In 2016 a scientific paper by the team of NASA scientists passed peer review for the first time. The paper suggests that the zero-point field acts as pilot-wave and that the thrust may be due to particles pushing off the quantum vacuum. While peer review doesn’t guarantee that a finding or observation is valid, it does indicate that independent scientists looked over the experimental setup, results, and interpretation and that they could not find any obvious errors in the methodology and that they found the results reasonable. In the paper, the authors identify and discuss nine potential sources of experimental errors, including rogue air currents, leaky electromagnetic radiation, and magnetic interactions. Not all of them could be completely ruled out, and further peer reviewed experimentation is needed in order to rule these potential errors out.